王晓林

王晓林 / 副研究员、硕导

Xiaolin Wang - 副本 (2)研究方向:生物芯片及微机电系统

电子邮箱:xlwang83@sjtu.edu.cn
办公电话:021-34206683
办公地点:综合实验楼2-309

网站: www.sjtubiomems.com

 

        王晓林,博士,现任上海交通大学电子信息与电气工程学院微纳电子学系副研究员,硕士生导师, 同时双聘为上海交通大学医疗机器人研究院副研究员。分别于2006年7月和2009年7月毕业于山东大学控制科学与工程学院,获得工学学士与工学硕士学位;2012年10月毕业于香港城市大学机械与生物医学工程系,获得博士学位。2013至2015年期间在美国加州大学欧文分校生物医学工程系从事博士后研究工作。目前,主要从事生物微机电系统以及微流控领域相关的研究工作,具体研究方向为:基于生物3D打印及微流控技术的仿人体器官芯片及其药物筛选应用,微纳机器人系统及其生物医学应用,微纳功能性结构与器件制备。

 

        近年来,作为项目负责人主持科研项目包括:国家自然科学基金面上项目1项、国家自然科学基金青年项目1项,上海市科委项目2项,国防重大科技专项子项目3项、军委科技委生物及交叉科学技术领域创新培育项目1项、以及校级项目2项;同时作为第二负责人参与上海市优秀学术带头人计划1项。共发表第一或通讯作者SCI期刊论文10余篇,其中以第一作者身份在国际微流控领域TOP期刊Lab on a Chip发表相关研究成果5篇。申请发明专利4项,包括美国专利3项。发表第一或通讯作者国际会议论文10余篇,主要包括3篇机器人与自动化领域国际会议ICRA 以及4篇微流控领域国际会议MicroTAS。相关研究成果获得第六届国际光流控交叉学术会议(IMCO 2016)最佳论文奖,以及教育部高等学校科学研究优秀成果奖(自然科学)二等奖。


研究方向:

  1. 基于生物3D打印及微流控技术的仿人体器官芯片及其药物筛选应用
  2. 微纳机器人系统及其生物医学应用
  3. 微纳功能性结构与器件制备

 

主要论文:

书籍章节:

  1. Qiyue Sun, Jianghua Pei, Qinyu Li, and Xiaolin Wang*, “Chapter 5: Vascularized microfluidic organ on a chip and its applications” in “Microfluidics and Bio-MEMS: Devices and Applications”, pp. 215-256, Jenny Stanford Publishing Pte. Ltd., May 2020.
  2. Xiaolin Wang, Duc T. T. Phan, Steven C. George, Christopher C. W. Hughes, and Abraham P. Lee,  “Chapter 24: 3D anastomosed microvascular network model with living capillary networks and endothelial cell-lined microfluidic channels” in “3D Cell Culture: Methods and Protocols”,  pp.325-344, Humana Press, 21 June
  3. Xiaolin Wang, Shuxun Chen, Dong Sun, “Chapter 16: Robot-aided micromanipulation of biological cells with integrated optical tweezers and microfluidic chip,” in “Micro- and Nanomanipulation Tools”, pp. 393-416, Wiley-VCH, November 2015.

主要期刊论文:

  1. Jianghua Pei, Qiyue Sun, Zhiran Yi, Qinyu Li, Xiaolin Wang*, Recoverable elastic barrier for robust hydrogel patterning with uniform flow profile for organ-on-a-chip applications, Journal of Micromechanics and Microengineering, 2020, 30(3), 035005.
  2. Xiaolin Wang#, Da Zhao#, Duc T.T. Phan, Jingquan Liu, Xiang Chen, Bin Yang, Christopher C.W. Hughes, Weijia Zhang * and Abraham P. Lee *, A hydrostatic pressure-driven passive micropump enhanced with siphon-based autofill function, Lab on a Chip, 2018, 18(15), 2167-2177. (Back cover)
  3. Duc T. T. Phan#, Xiaolin Wang#, Brianna M Craver, Agua Sobrino, Da Zhao, Jerry C Chen, Lilian Y.N. Lee, Steven C George, Abraham Lee* and Christopher Hughes*, A vascularized and perfused organ-on-a-chip platform for large-scale drug screening applications, Lab on a Chip, 2017, 17(3), 511-520.
  4. Xiaolin Wang, Duc T. T. Phan, Da Zhao, Steven C. George, Christopher C. W. Hughes*, and Abraham P. Lee*, An on-chip microfluidic pressure regulator that facilitates reproducible loading of cells and hydrogels into microphysiological system platforms, Lab on a Chip, 2016, 16(5), 868-876.
  5. Xiaolin Wang#, Duc T. T. Phan#, Agua Sobrino, Steven C. George, Christopher C. W. Hughes*, and Abraham P. Lee*, “Engineering anastomosis between living capillary networks and endothelial cell-lined microfluidic channels,” Lab on a Chip, 2016, 16(2), 282-290.  (Back cover)
  6. Xiaolin Wang, Shuxun Chen, Yu Ting Chow, Chi-wing Kong, Ronald A. Li and Dong Sun, “A microengineered cell fusion approach with combined optical tweezers and microwell array technologies,” RSC Advances, 2013, 3: 23589-23595.
  7. Xiaolin Wang, Xue Gou, Shuxun Chen, Xiao Yan, and Dong Sun, “Cell manipulation tool with combined microwell array and optical tweezers for cell isolation and deposition,” Journal of Micromechanics and Microengineering, 2013, 23(7): 075006.
  8. Xiaolin Wang, Shuxun Chen, Marco Kong, Zuankai Wang, Kevin D. Costa, Ronald A. Li, and Dong Sun, “Enhanced cell sorting and manipulation with combined optical tweezer and microfluidic chip technologies,” Lab on a Chip, 2011,11(21): 3656-3662.

主要会议论文:

  1. Jianghua Pei, Qiyue Sun, and Xiaolin Wang*, A plug-n-play hydrostatic pressure-driven pump module for high-throughput organ-on-a-chip applications, The 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2018), pp. 1655-1657, Kaohsiung, Taiwan, 2018.
  2. Xiaolin Wang*, Da Zhao, and Abraham P. Lee*, Enhanced hydrostatic pressure-driven passive micropump with siphon-based autofill function, The 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2017), pp.643-644, Savannah, Georgia, 2017.
  3. Xiaolin Wang, Duc Phan, Steven C. George, Christopher C. W. Hughes, and Abraham P. Lee, Well plate-based microfluidic platform for high throughput screening of 3D perfused vascularized microtissue, The 6th International Multidisciplinary Conference on Optofluidics (IMCO 2016), Beijing, China, 2016. (Best Paper Award)
  4. Xiaolin Wang, Duc Phan, Steven C. George, Christopher C. W. Hughes, and Abraham P. Lee, Pressure regulator for roust gel injection in coupling microfluidic chip for 3D microvascular tissue, The 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2015), pp. 740-742, Gyeongju, Korea, 2015.
  5. Xiaolin Wang, Duc Phan, Steven C. George, Christopher C. W. Hughes, ​and Abraham P. Lee, Engineering anastomosis between biological perfused vessel network and endothelial cell-lined microfluidic channel, The 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2014), pp. 748-750, San Antonio, TX, 2014.
  6. Xiaolin Wang, Shuxun Chen, Chi-wing Kong, Ronald A. Li and Dong Sun, “Automatic laser-induced cell fusion based on microwell array,” IEEE International Conference on Robotics and Automation(ICRA2013), Karlsruhe, Germany, pp. 2780-2785, 2013.
  7. Xiaolin Wang, Xiao Yan, Shuxun Chen and Dong Sun, “Automated parallel cell isolation and deposition using microwell array and optical tweezers,” IEEE International Conference on Robotics and Automation(ICRA2012), Saint Paul, MN , pp. 4571-4576, 2012.
  8. Xiaolin Wang, Shuxun Chen and Dong Sun, “Robot-assisted automatic cell sorting with combined optical tweezer and microfluidic chip technologies,” IEEE International Conference on Robotics and Automation (ICRA2011), Shanghai, China, pp. 6003-6008, 2011.

发明专利:

  1. Abraham P. Lee, Tao Yue, Da Zhao, Xiaolin Wang, Multi-layered Microfluidic Systems for In Vitro Large-scale Perfused Capillary Networks, US Patent, Pub. No.: US 2019/0119619 A1.
  2. Abraham P. Lee, Xiaolin Wang, Duc T. T. Phan, Christopher C. W. Hughes, and Steven C. George, Microfluidic Pressure Regulator for Robust Hydrogel Loading without Bursting, US Patent, Pub. No. : US 2017/0130187 A1.
  3. Dong Sun, and Xiaolin Wang, “Methods and Means for Manipulating Particles.” US Patent. US8723104 B2.

 

科研项目(主持)

  1. 国家自然科学基金面上项目(31972929):2020-2023
  2. 国家自然科学基金青年项目(31600781):2017-2019
  3. 上海市科委“科技创新行动计划”基础研究领域项目(17JC1400202):2017-2020
  4. 上海市科委自然科学基金探索类(微纳技术前沿基础)(19ZR1475000):2019-2022
  5. 军委科技委生物及交叉科学技术领域创新培育项目:2017-2018
  6. 国防重大专项子项目:2016-2020
  7. 上海交通大学医工交叉面上项目(YG2016MS06):2017-2019(结题获学校“优秀”评定

 

获奖情况

  1. 2019年度教育部高等学校科学研究优秀成果奖(自然科学)二等奖(排名7): 基于机器人技术的细胞微纳操作理论与方法
  2. 第六届国际光流控交叉学术会议(IMCO 2016)最佳论文奖

 

《生物芯片技术》

微纳电子学系